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These metrics are regularly updated to reflect usage leading up xxx the last few days. Citations are the number of other articles citing this article, calculated xxx Julia paes photos and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online.

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Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. Nanoparticles have been extensively used to deliver therapeutic drugs to tumor tissues through extravasation from a leaky vessel via enhanced permeation and retention effect EPR, passive targeting penatration targeted interaction of tumor-specific ligands active targeting. However, the penatration efficacy of drug-loaded nanoparticles is hampered by heterogeneous distribution owing to limited penetration in tumor tissue.

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Inspired by harfcore father daughter fact that cancer cells can recruit inflammatory immune cells to support their survival, deep developed a click reaction-assisted immune cell targeting CRAIT strategy to deliver drug-loaded nanoparticles deep into avascular regions of the tumor.

Immune cell-targeting CD11b antibodies are modified with trans-cyclooctene to enable deep click chemistry with mesoporous silica nanoparticles functionalized with tetrazines MSNs-Tz. We show that the CRAIT strategy allows deep tumor penetration of drug-loaded nanoparticles, resulting in enhanced therapeutic efficacy in an orthotopic 4T1 breast tumor model.

The CRAIT strategy does not require ex vivo manipulation of cells and can be applied to various types of cells and nanovehicles.