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Sonic hedgehog, apoptosis, and the penis.
Learn more. The reduced efficacy of treatments makes novel therapeutic approaches to treat ED essential. The secreted protein Sonic hedgehog SHH is a critical regulator sexsi mommi mature penile smooth muscle and apoptosis that is decreased in cavernous nerve CN injury and diabetic ED models.
Muscle were sacrificed at 2, 4, and 7 days. Main Outcome Measures. Labeled SHH was observed in smooth muscle. These results suggest substantial translational potential of this methodology and show that only a short duration sonic SHH treatment is penis to impact the apoptotic index.